A post doctoral position is available in Lab of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, to study cellular mechanism of HIV infection induced host cell signaling for potential development of antiviral therapies. In particular, we are interested in targeting potential host genes and pathways to facilitate HIV-induced viral release. We recently identify L-selectin (CD62L) as a viral adhesion receptor on CD4+ T cells. The binding of viral envelope glycans to CD62L facilitates HIV entry and infection, and L-selectin expression on central memory CD4+ T cells supports their preferential infection by HIV. Upon infection, the virus downregulates L-selectin expression through shedding, resulting in an apparent loss of central memory CD4+ T cells. Furthermore, inhibition of L-selectin shedding markedly reduces HIV-1 infection and suppresses viral release, implementing L-selectin shedding for HIV-1 release (Kononchik et al. HIV-1 Targets L-selectin for adhesion and induces its shedding for viral release. Nat Commun July 19;9(1):2825, 2018). For more information, please refer to https://www.niaid.nih.gov/research/peter-sun-phd
Qualified candidate should have a PhD degree obtained within past five years in related research fields. Interested candidates should send a letter of application and C.V. to Dr. Peter Sun, firstname.lastname@example.org.