Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

The Nabet laboratory is recruiting a highly motivated postdoctoral fellow to carry out research in the fields of targeted protein degradation and proximity-induced therapeutics. The goals of our research program are to develop strategies to target cancer drivers by controlling protein homeostasis to gain new biological insights into clinically relevant targets and to advance new therapeutic strategies in cancer. The Nabet laboratory develops and deploys innovative chemical biology technologies such as the dTAG system to rapidly eliminate target proteins for therapeutic target discovery and validation (Nabet et al., Nature Chemical Biology 2018; Nabet et al., Nature Communications 2020). The Nabet laboratory is highly collaborative and works extensively with medicinal chemists to develop inhibitors and degraders for cancer drug targets (Ferguson and Nabet et al., Nature Chemical Biology 2020; Li et al., European Journal of Medicinal Chemistry 2022). We are committed to supporting the next-generation of scientists and believe in collaborative science (Nabet, ChemBioChem 2021). This is an exceptional opportunity to join a new team that is pushing the boundaries of cancer chemical biology.

Responsibilities

We are seeking candidates that will drive rigorous scientific projects utilizing state-of-the-art targeted degradation approaches including the dTAG system, chemical probes, genome-wide CRISPR knockout screens, molecular biology, biochemistry, next-generation sequencing, and in vivo murine modeling, with the goal of understanding the mechanisms of oncogenes in cancer and developing new therapeutic approaches. The position will require both independent research as well as the ability to collaborate closely with medicinal chemists, computational biologists, and other colleagues.

Qualifications

Minimum Qualifications:

 - A recent PhD, and/or MD and a track record of independent productive research.

 - Excellent written and verbal communication skills are required.

 - A strong foundation in cell culture, genetic engineering, next-generation sequencing, murine modeling, molecular biology, biochemistry, and/or chemical biology is highly desirable.

 - Fellowship opportunities are available through several philanthropic and government organizations and recruits who join the lab will be supported in their applications.

Application instructions:

Please apply by submitting a CV, a brief description of past research experiences and future goals (not more than 1-2 pages), and contact information for three references.

The annual base salary range for this position is from $67,728 to $100,000 and pay offered will be based on experience and qualifications. 

This position may be eligible for relocation assistance.