Scientist, Functional Genomics & Infectious Disease

Chan Zuckerberg Biohub

Categories:
  • Research Scientist
Job Type/Arrangement:
  • Full Time
Description:

Description

The Chan Zuckerberg Biohub ("CZ Biohub”) is an independent nonprofit medical research organization based in the San Francisco Bay Area. The Chan Zuckerberg Biohub supports scientific research to cure, prevent or manage disease in our children’s lifetime. Our mission is to understand the fundamental mechanisms underlying disease and to develop new technologies which will lead to actionable diagnostics and effective therapies. We harness the power and possibility of collaboration to drive discovery and set the standard for open, impactful science. For more information, please visit czbiohub.org.


Opportunity


As part of a new intramural collaborative effort that spans our Infectious Disease, Cell Atlas, and Technology Initiatives, we aim to comprehensively dissect viral replication and immune responses that control or acerbate disease outcome. Our goal is to uncover the biological mechanisms behind virus-host interactions, and exploit this new knowledge to develop new therapeutic strategies.


We are seeking an outstanding Scientist to join the research group of Dr. Andreas Puschnik to develop and implement new functional genomics approaches for the interrogation of cellular pathways important for infection and immunity.


Responsibilities


  • The candidate will have the opportunity to spearhead a project that will involve:

  • -Molecular engineering of viral and cellular reporters
  • -Large-scale and targeted mutagenesis using CRISPR-based editing techniques (e.g. Cas9, base editing, Cas13)
  • -Mechanistic studies that will leverage the collaborative and technology-rich environment at CZ Biohub (microscopy, proteomics, scRNA-seq, flow cytometry)
  • -Data analysis and presentation of results during lab meetings/seminars
  • -Author publications and mentor junior colleagues


Requirements
-PhD (or equivalent) in Molecular and Cell Biology, Genetics, Microbiology, Immunology, Bioengineering or related disciplines.
-Experience with mammalian cell culture, transfection and lentivirus production.
-Expertise in CRISPR-Cas9 gene editing and/or related techniques (base editing, prime editing, Cas13 RNA editing).
-Hands-on experience in a wide variety of cell biology & molecular biology techniques including nucleic acid purification, qPCR, molecular cloning, Western Blot, fluorescence microscopy, flow cytometry etc.
-Experience with large-scale screens and analysis of large datasets is desired.
-Coding experience (e.g. Python, R etc.) is preferred.
-Experience with BSL-2 infection models is not required but a plus.
-Must be able to work independently and as part of a team; excellent written and oral communication skills required.


What We Provide

  • -Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease.
  • -A collegial and collaborative environment consisting of diverse expertise.
  • -Existing collaborations within CZ Biohub: Advanced Optical Microscopy, Cell Atlas, Bioengineering, Data Science, Genome Editing, and Infectious Diseases.
  • -Access to collaborators, resources and facilities at the three partner campuses (UCSF, Berkeley and Stanford) and at partner institutions in the Bay Area and beyond.
  • -Competitive compensation and benefits commensurate with the experience.

Benefits

We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.


CZ Biohub is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.


Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.


Headhunters and recruitment agencies may not submit resumes/CVs through this Web site or directly to managers. CZ Biohub does not accept unsolicited headhunter and agency resumes. CZ Biohub will not pay fees to any third-party agency or company that does not have a signed agreement with CZ Biohub.

Education Requirement:
PhD (or equivalent) in Molecular and Cell Biology, Genetics, Microbiology, Immunology, Bioengineering or related disciplines.
Location:
San Francisco campus
499 Illinois St
4TH FLOOR
San Francisco , CA 94158
US
Contact:
Andreas Puschnik,