Description of the lab: https://pimit.univ-reunion.fr
The Research Unit (UMR) "Infectious Processes in Tropical Island Environments, acronym PIMIT" (Director Patrick MAVINGUI) hosts associate and full Professors, researchers, engineers and technicians from the Reunion University, INSERM (U1187), CNRS (9192) and IRD (249). It is located in Saint-Denis de La Réunion at the CYROI research platform (Reunion Cyclotron, 2 rue Maxime Rivière, 97490 Ste Clotilde). This unit of about 40 members (20 permanents and 20 non permanents) conducts research on zoonotic infectious diseases in Reunion Island and in the South-West Indian Ocean Islands. PIMIT is structured in 2 research teams: Dynamics of Infectious agents in Insular Systems (acronym DySIIs) and Molecular and Cellular Mechanisms of Pathogenic Infectious Agents (acronym MOCA) led by Pr. Philippe DESPRÈS. MOCA is a team specialized in the study of the molecular and cellular mechanisms of RNA viruses of medical importance. Two research axes are carried out within the MOCA team, the first one focuses on infectious pathologies with a target on pathogenicity and host response. The second research axis focuses on anti-infectious strategies through vaccinology and antiviral strategies using medicinal plants as a source of active molecules. Successful collaborations have been established with research groups within France, Europe, Brazil and USA and their themes are supported by European H2020 (ZIKAlliance) and FEDER Région Réunion 2015-20 (ZIKAlert and PHYTODENGUE) programs as well as R&D partnerships with SMEs supported by Inserm Transfert.
Description of the job
In response to the recent emergence of dengue (DENV) disease in La Reunion associated to the introduction of three DENV serotypes leading a major risk of dengue hemorrhagic fever, it was decided to develop PHYTODENGUE program, an international scientific consortium sharing complementary expertise in the fields of phytochemistry, medicinal chemistry and molecular virology, from the Indian Ocean (UMR PIMIT, LIA (University of Antananarivo), UR CHEMBIOPRO), France (ICSN) and Belgium (Neyts Lab, KU Leuven).
The "hot spot" status of the biodiversity of Madagascar and Reunion Island makes them possible to envisage the discovery of anti-DENV compounds isolated from plant biodiversity. This consortium has, (i) a strong experience in the collection of relevant biological material in the Indian Ocean region, (ii) the expertise for the characterization and processing of this material, (iii) the expertise for identifying antiviral activity of novel compounds employing cell-based assays, bio-guided fractionation, molecular network using metabolomic approach (iv) the expertise for validation of toxicology and antiviral activity using a relevant in vivo model for DENV infection.
For this purpose, the University of La Reunion, UM 134 PIMIT, is seeking a highly talented and motivated postdoctoral candidate to join MOCA team as part of PHYTODENGUE research program. The postdoctoral fellow will characterize the antiviral activity of novel compounds isolated from medicinal plants. The candidate must have a PhD in virology with a post-doctoral experience of at least 3 years. Strong experience with molecular virology, inverse genetic, molecular biology, cell cultures in BSL3 and flow cytometry is expected. Good command of the English language, both speaking and writing, is a must. The applicant will be expected to prepare and publish manuscripts, present data at local and international meetings, to carry out missions within the laboratories of the consortium. The successful candidate must have independent research abilities and ambitious scientific goals.
Please submit your cover letter, CV, and names and contact information for at least 3 references.