An NIH/NIAID funded position is available to study seasonal influenza A virus infection of primary differentiated human nasal epithelial cell (hNEC) cultures. Both human H1N1 and H3N2 influenza viruses cause different degrees of disease severity. Importantly, these viruses also have different replication rates and induce unique innate immune responses in hNEC cultures. In addition, numerous mutations that accumulate in human influenza viruses can alter virus replication and recognition by preexisting immune responses. These differences penetrate to a greater degree in primary human nasal epithelial cell cultures and at physiologically relevant temperatures when compared to standard cell culture models. This position will study both viral and cellular factors that mediate these changes in replication rates and responses to infection.
Candidates with a strong background in virology, molecular biology, cell biology and/or biochemistry should send a cover letter CV and the names/email addresses of three references to:
Andrew Pekosz, Ph.D.
W. Harry Feinstone Department of Molecular
Microbiology & Immunology
Johns Hopkins University
Bloomberg School of Public Health
615 North Wolfe Street, rm W2116
Baltimore, MD 21205-2103