Job description: Multiple post-doctoral/research scientist positions are immediately available at the Ohio State University/Nationwide Children’s Hospital (Columbus, OH) to study the hepatitis virus life cycle and pathogenesis. Hepatitis A virus (HAV) and hepatitis E viruses (HEV) are both enterically transmitted hepatotropic RNA viruses and thought to be non-enveloped for decades. However, recent studies have revealed that the virus released from cells and circulating in the patient's blood is completely cloaked in host membranes and resistant to neutralizing antibodies (Feng et al., Nature, 2013). The discovery of this novel enveloped form has raised a series of questions about the fundamental biology of HAV and HEV and how these viruses interact with their host (Feng & Lemon, Trends Microbiol, 2014; Feng et al., Annu Rev Virol, 2014). In addition, we recently discovered a capsid-mimicking decoy protein in HEV that potentially alters the humoral and cellular responses during acute and chronic infections (Yin et al., PNAS, 2018). Projects are directed to understand (1) how enveloped virions are produced at the apical and basolateral sides of polarized hepatocytes and how they enter the cell and become neutralized by antibodies, and (2) what role(s) the decoy protein plays during HEV infections. Opportunities also exist to work on the entry and exit mechanisms for the hepatitis B and D viruses.
Responsibilities: The successful candidate is expected to have excellent technical and communication skills, perform self-directed research, and assist the PI in preparing manuscripts and grant applications.
Minimum requirements: Candidates must have a PhD or equivalent with strong research experience in molecular biology, virology, or cell biology. Applicants with experience in RNA Seq, proteomics, and/or bioinformatics are particularly encouraged to apply. Competitive salary will be commensurate with experience (NIH recommended salary for postdocs). Interested applicants should submit a single PDF file consisting of a CV, a brief description of their research achievements and interests, and a list of 3 references to Dr. Zongdi Feng (Zongdi.Feng@nationwidechildrens.org).