Postdoctoral Research Fellow: Characterization of viral hormones in host-pathogen interactions

BOSTON COLLEGE

Categories:
  • Post Doctoral Position - Academic
Job Type/Arrangement:
  • Full Time
Description:

Viral hormones

Altindis Lab at Boston College Biology Department is seeking a highly motivated postdoctoral fellow who is interested in studying the role of viral hormones, in particular, viral insulin/IGF-1 like peptides in host-pathogen interactions. The focus of Altindis Lab is to understand the role of microbial mimicry mechanisms in human diseases and characterize these factors to further our understanding of their role in human disease. We recently discovered the presence of viral hormones, in particular, viral insulin/IGF-1 like peptides (VILPs)*.  We showed that viral insulins can bind both human insulin and IGF-1 receptors, stimulate post-receptor signaling. VILPs can also stimulate in vivo and in vitro glucose uptake.  We seek a productive and independent postdoctoral fellow to join us working on this project.

 * https://www.pnas.org/content/115/10/2461

  •  Qualifications
  •  Appointee recently awarded a Ph.D. or equivalent doctorate (e.g., Sc.D., M.D.) in Virology, Microbiology or a related field. 

  • The ability to perform creative and independent research. 
  • Experience with large dsDNA viruses and basic virology assays (plaque, isolation, infection, apoptosis, proliferation). 
  • Experience with making the viral knock out models of viruses; bacterial artificial chromosome and/or CRISPR. 
  • Next-generation sequencing library preparation and analysis is a plus. 
  • Experience with basics, isolating DNA, RNA, and protein from tissues and cells, PCR, qPCR, Western Blot and microscopy. 
  • Experience of mammalian cell culture of primary cells and cell lines. 
  • Transfection of animal models and cell lines using AAV and lentivirus models. 
  • Demonstrated scientific excellence; evidenced by publication track record as well as track record of presenting at national and international meetings. 
  • Experience with cloning. 
  • Excellent oral and written communication skills in English. 

Highly desired:

Experience with bioinformatics (R) 

Experience with genomics, library preparation, and RNAseq

Experience with virome research is highly desired

Experience with the phage display method

Experience with insulin, FGF or endothelin biology

NIH Postdoctoral Fellow Minimum Full Time Equivalent Stipend: $48,432.

Closing Statement

Boston College conducts background checks as part of the hiring process.

Boston College is an Affirmative Action/Equal Opportunity Employer and does not discriminate on the basis of any legally protected category including disability and protected veteran status. To learn more about how BC supports diversity and inclusion throughout the university please visit the Office for Institutional Diversity at http://www.bc.edu/offices/diversity. 

Benefits:
BC Benefits Package
Education Requirement:
PhD
Required Skills & Areas of Study:
  • dsdna viruses
  • iridoviridae
  • next gen sequencing
  • animal viruses
Salary:
NIH Postdoctoral Fellow Minimum Full Time Equivalent Stipend: $48,432.
Notes:

Experience with dsDNA viruses and gene knock outs is essential.

Location:
Altindis Lab, Higgins Hall
Biology Department
Boston College, 515, Higgins Hall, 140 Commonwealth Avenue
140 Commonwealth Avenue
Chestnut Hill , Massachusetts 02467
US
Contact:
EMRAH ALTINDIS, PhD