We have developed new technologies to identify undiscovered human cancer viruses. Our past work discovered KSHV/HHV8, the cause of Kaposi sarcoma, and Merkel cell polyomavirus, the only polyomavirus causing human cancer. Digital transcriptome subtraction (DTS) used to discover Merkel cell polyomavirus was the first use of a non-directed human sequencing pipline to identify a human viral pathogen. In collaboration with the University of Pitt BioMS Center (http://www.bioms.pitt.edu/resources.html), which has a full suite of proteomic resources, we are evaluating a new initiative for virus discovery using proteomics. It is anticipated that the applicant will be able to contribute to--and expand on--an established and working experimental procedure . This project is supported by long-term R35 funding. Successful candidates will have strong molecular biology skills, superior publication record and an appetite for creative yet rigorous research. Expertise with mass spectrometry, immunohistochemistry, UNIX-based bioinformatics, transcriptomics and proteomics are helpful though not required. Willingness to learn these and other techniques is essential. While a virology background is helpful, exceptional MD/PhD graduates with a strong research track record in other areas are welcome to apply.
Please contact Patrick S. Moore (firstname.lastname@example.org) and Yuan Chang (email@example.com), Cancer Virology Program. Res Pav 1.8, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213 http://www.tumorvirology.pitt.edu