Postdoctoral Scholar to study Kaposi’s sarcoma-associated herpesvirus (KSHV) oncogenesis in Dr. Jennifer Corcoran’s lab

University of Calgary

Categories:
  • Post Doctoral Position - Academic
Job Type/Arrangement:
  • Fellowship
Description:

Postdoctoral Scholar position

Area: Viral Oncogenesis

Duration: Contract for 1 year, renewable for up to 5 years.

Start date: Oct 1, 2022 – Jan 1, 2023.

                    Applications will be accepted until the best match is found.

Salary: 45,000 to 50,000 $CAD per year commensurate with experience (plus Alberta Blue Cross health insurance benefits)

The Department of Microbiology, Immunology and Infectious Diseases in the Cumming School of Medicine at the University of Calgary is accepting applications for a Postdoctoral Scholar to study Kaposi’s sarcoma-associated herpesvirus (KSHV) oncogenesis in Dr. Jennifer Corcoran’s lab.

Twitter: Corcoran Lab @corcoran_lab

Job Description:

Join a lively, productive, and growing virology laboratory; collaborate with Canadian and international scientists working in the KSHV oncogenesis field; and learn cutting-edge techniques such as single-cell RNA sequencing and synthetic virology! The Corcoran lab is seeking a motivated and hard-working postdoctoral scholar for Canadian Institutes of Health Research (CIHR)- funded research on the oncogenic virus, Kaposi’s sarcoma-associated herpesvirus (KSHV).

The Corcoran lab is seeking a motivated and hard-working postdoctoral scholar for a Canadian Institutes of Health Research (CIHR)- funded project on the role of the Kaposi’s sarcoma-associated herpesvirus (KSHV) kaposin locus in latency establishment after primary infection. KSHV causes the endothelial cell cancer, Kaposi’s sarcoma (KS). Unlike many tumours caused by viruses, KS maintenance and spread relies on KSHV replication.

For KSHV primary infection to establish a latent infection, the virus induces an initial burst of viral gene expression and genome copying while also limiting cellular antiviral responses designed to reduce its replication. We seek to better understand these steps using a resource unique to our lab, a suite of KSHV mutants targeting the viral kaposin locus. We have discovered that all kaposin-deficient mutants tested displayed defects in genome copying after primary infection. We are now engaged in the fascinating analysis of this phenotype using single-cell RNA sequencing, chromatin immunoprecipitation, and advanced immunofluorescence microscopy including DNA and RNA fluorescent in situ hybridization.

Kleer, MacNeil, Adam, Pringle, and Corcoran. A Panel of Kaposi's Sarcoma-Associated Herpesvirus Mutants in the Polycistronic Kaposin Locus for Precise Analysis of Individual Protein Products. 2022. J Virol. Mar 9;96(5):e0156021. doi: 10.1128/JVI.01560-21.

The postdoctoral scholar will report to Dr. Jennifer Corcoran and work alongside a vibrant and diverse group of doctoral and master’s trainees in the Corcoran lab. The Corcoran lab is a welcoming and inclusive work environment where students and employees receive weekly guidance and mentorship from Dr. Corcoran. With this project, the postdoctoral scholar will have the opportunity to further develop skills in molecular cloning/recombinant virology, primary cell culture, advanced fluorescent microscopy techniques including fluorescent in situ hybridization, chromatin immunoprecipitation, mass spectrometry and single-cell RNA sequencing. These techniques will permit study of the fascinating interplay between KSHV and cellular DNA damage responses as it pertains to viral primary infection and replication. In addition, the postdoctoral scholar will be provided with career development opportunities including but not limited to the mentorship of junior trainees working on the project.

This is a full-time, fixed-term position for one year. The period of employment may be extended depending on satisfactory performance. Funds are available for this project for five years.

Qualifications:

• Recent* PhD in molecular virology or a closely related field.

• Experience with molecular cloning is essential; experience with recombinant virology is an asset.

• Experience with standard molecular biology techniques and immunofluorescent microscopy is essential; experience with chromatin immunoprecipitation or DNA damage responses will be deemed an asset

• Experience with the biology of herpesviruses or oncogenic viruses preferred

• Strong communication skills (both written and verbal) including strong listening skills, as evidenced by a record of publication, presentation, and scholarship

• Ability to work in a team environment, as evidenced by a track record of collaborative publication.

• Strong organizational, time management and problem-solving skills, while maintaining accuracy and attention to detail

• An understanding of statistical packages for data analysis and interpretation.

• Enthusiasm for academic research and mentorship of junior trainees.

*Please review the Postdoc Eligibility Guidelines for more information prior to applying for this position.

Application details:

Interested applicants should contact Dr. Jennifer Corcoran via email jennifer.corcoran@ucalgary.ca . Inquiries must include a cover letter summarizing the applicant’s relevant experience and reason for their interest in the position as well as a detailed curriculum vitae and the contact information for three academic references. Initial interviews will be conducted via Zoom. Enthusiastic applicants are encouraged to contact Dr. Corcoran as soon as possible as funds are immediately available for this project.

About the University of Calgary

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university has reached its Eyes High goal to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca.

The terms and conditions of employment are covered under the UCalgary and PDAC Collective Agreement. To find out more about postdoctoral scholar program at the University of Calgary visit our Postdocs website. All international postdoctoral scholars whose initial appointment is for 12 months or longer will be eligible to receive the Alberta Health Care Insurance Plan (AHCIP). The AHCIP provides Alberta residents with coverage for hospital and physician services. Postdoctoral Associates with appointments greater than 6 months have access to extended health and dental benefit coverage. The University of Calgary also provides eligible Postdoctoral Associates with paid maternity and parental leave benefits.

About Calgary, Alberta, Canada

Calgary is less than an hour’s drive from the Rocky Mountains and boasts the most extensive urban pathway and bikeway network in North America. Calgary is one of the world's cleanest cities and has been named one of the world's most livable cities for years. Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.


Benefits:
Basic health benefits, extended health and dental (>6 months), access to maternity/parental benefits
Education Requirement:
BSc. PhD in molecular virology
Years of Experience:
5 years graduate school
Required Skills & Areas of Study:
  • molecular virology studies
  • molecular cell biology
Salary:
45000-50000
Location:
Cumming School of Medicine, Foothills Campus
Microbiology, Immunology and Infectious Diseases
3330 Hospital Drive NW
HRIC2B31
Calgary , AB T2N 1N4
CA
Contact:
Jennifer Corcoran, PhD