We are inviting applications for a Postdoctoral Fellowship position to help lead an NIH-funded project investigating delivery of gene therapies to the brain for the treatment of neurological disorders. Our laboratory uses the technology of focused ultrasound (FUS) to temporarily disrupt the blood-brain barrier for delivery of drugs and gene therapies to the brain. This preclinical project aims to deliver an AAV-packaged micro-RNA therapy targeting the gene implicated in Huntington’s disease. We envision the methods developed here will be applicable to a range of gene therapy and neurological disorder combinations.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

• Lead studies to optimize FUS-mediated delivery of AAV vectors in a mouse model.

• Design and carry out FUS-BBB opening experiments in mice.

• Harvest, section, stain, and image brains for markers of treatment safety and efficacy.

• Organize and analyze data.

• Present findings at scientific meetings and publish results in scientific journals.

QUALIFICATIONS:

• PhD in Immunology, Microbiology, Virology, Bioengineering, Neuroscience or related discipline.

• Strong publication record.

• Previous research experience with gene therapies, AAV vectors or focused ultrasound.

• Self-motivated and independent worker.

• Ability to work with others in an inter-disciplinary team.

All qualified applicants will receive consideration for employment without regard to gender,

race, color, religion, sex, national origin, disability, age or protected veteran status. 

To apply, please send a statement of interest, along with a resume to Dr. Nick Todd at: ntodd1@bwh.harvard.edu. Subject line should read “Last Name: PostDoc Position”.