The Cliffe lab at UVA has an opening for a Postdoctoral Research fellow to investigate Herpes Simplex Virus latency. Our laboratory uses a variety of novel approaches including in vitro models of HSV latency in primary neurons, and in vivo infections, in addition to human induced neurons. We combine these with cutting edge molecular biology approaches and imaging analyses to investigate the epigenetics of HSV neuronal infection and the host response. The position would be ideal for anyone with an interest in viral infection, neurobiology and/or innate immunology, and in establishing novel models to investigate viral infection of human neurons. The ideal candidate has a PhD with experience in relevant areas of biology, first-author publication(s), and ability to work well in a highly interactive, creative, and collaborative environment.
Our recent publications:
Dochnal, SA, Francois, AK. Cliffe AR. De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses. Viruses 2021 13(8), 1470. https://doi.org/10.3390/v13081470.
Suzich JB, Cuddy S, Baidas H, Dochnal S, Ke E, Schinlever AR, Babnis A, Boutell C, Cliffe AR. PML-NB Dependent Type I Interferon Memory Results in a Restricted Form of HSV Latency. EMBO Reports 2021 e52547. https://doi.org/10.15252/embr.202152547.
Cuddy S, Schinlever AR, Dochnal S, Suzich J, Kundu P, Downs TK, Farah M, Desai B, Boutell C, Cliffe AR. Neuronal hyperexcitability is a DLK-dependent trigger of HSV-1 reactivation that can be induced by IL-1. eLife 2020 Dec 22;9:e58037. doi: 10.7554/eLife.58037.
Cliffe AR. DNA Damage Meets Neurotrophin Signaling: A Delicate Balancing AKT to Maintain Virus Latency. Molecular Cell. 2019 May 2;74(3):411-413. doi: 10.1016/j.molcel.2019.04.015.
Cliffe AR, Arbuckle JH, Vogel JL, Geden MJ, Rothbart SB, Cusack CL, Strahl BD, Kristie TM, Deshmukh M. Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation., 2015; Cell Host & Microbe. 18(6) 649-58.
Find out more about the Cliffe lab here -