The Post Doctoral Scientist is responsible for conducting basic and applied research as an individual contributor in the Elanco Research Labs and the Virology Research group. The primary research project will involve molecular, structural, and functional elucidation of virus attachment and fusion glycoproteins. This information will be applied to rational design of viral antigens in order to elicit more potent immune responses to veterinary infectious diseases. A strong foundation in molecular biology techniques and structural biology will be required to succeed within the team. The ability to independently conceptualize and execute experiments, coupled with a “can do” attitude, is essential.
Design, model, express, and purify proteins of interest, and characterize them using a variety of biochemical and biophysical techniques
Determine protein structural information using techniques such as crystallization, electron microscopy, and Cryo-EM
Analyze oligomeric protein complexes from biochemical and structural perspectives
Perform mutagenesis of protein expression plasmids. Analyze mutation phenotypes and design follow-up experiments
Create recombinant viruses and cell lines expressing genes of interest
Design and build cell and virus-based assays to assess and quantify protein function
Participate in cross-functional research teams and effectively collaborate with other functional groups in the organization
Enable the timely progression of research projects through the practical application of scientific expertise which may include planning, protocol creation, hands-on laboratory work
Keep abreast of relevant scientific literature/new technologies /capabilities.
Proactively search for novel technologies or product opportunities and establish collaborations and research programs to deliver innovative technical solutions
Demonstrates proficiency at data reporting, interpretation, and trending.
Demonstrates good documentation skills with regard to raw data recording and protocol authoring
PhD degree in virology, immunology, structural biology, molecular biology or related scientific discipline and/or M.D. or D.V.M.
This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years.
Broad knowledge of Virology and Molecular Biology principles including molecular cloning, PCR, Gibson Assembly, nucleic acid extraction, purification, & sequence analysis
Proficiency with mammalian cell culture
Extensive experience with protein biochemistry, including recombinant protein expression and purification and co-immunoprecipitations
Experience with structural elucidation of viruses and/or oligomeric protein complexes including crystallography and/or CryoEM
Effective oral and written communications skills.
High personal ethical and quality standards.
Exceptional problem solving and decision-making skills.
Must be able to work productively in an interdisciplinary team environment
Occasional travel (mainly US).
Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status