Post Doctoral Scientist-FDE

(Ref#: R0003324)

Elanco Animal Health

  • Industry
  • Post Doctoral Position - Industry
  • Research Scientist
Job Type/Arrangement:
  • Full Time

The Post Doctoral Scientist is responsible for conducting basic and applied research as an individual contributor in the Elanco Research Labs and the Virology Research group. The primary research project will involve molecular, structural, and functional elucidation of virus attachment and fusion glycoproteins. This information will be applied to rational design of viral antigens in order to elicit more potent immune responses to veterinary infectious diseases. A strong foundation in molecular biology techniques and structural biology will be required to succeed within the team. The ability to independently conceptualize and execute experiments, coupled with a “can do” attitude, is essential.
Key Objectives/Deliverables:

    Design, model, express, and purify proteins of interest, and characterize them using a variety of biochemical and biophysical techniques

    Determine protein structural information using techniques such as crystallization, electron microscopy, and Cryo-EM

    Analyze oligomeric protein complexes from biochemical and structural perspectives

    Perform mutagenesis of protein expression plasmids. Analyze mutation phenotypes and design follow-up experiments

    Create recombinant viruses and cell lines expressing genes of interest

    Design and build cell and virus-based assays to assess and quantify protein function

    Participate in cross-functional research teams and effectively collaborate with other functional groups in the organization

    Enable the timely progression of research projects through the practical application of scientific expertise which may include planning, protocol creation, hands-on laboratory work

    Keep abreast of relevant scientific literature/new technologies /capabilities.

    Proactively search for novel technologies or product opportunities and establish collaborations and research programs to deliver innovative technical solutions

    Demonstrates proficiency at data reporting, interpretation, and trending.

    Demonstrates good documentation skills with regard to raw data recording and protocol authoring

Basic Qualifications

    PhD degree in virology, immunology, structural biology, molecular biology or related scientific discipline and/or M.D. or D.V.M.
    This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years.

Additional Skills/Preferences:

    Broad knowledge of Virology and Molecular Biology principles including molecular cloning, PCR, Gibson Assembly, nucleic acid extraction, purification, & sequence analysis

    Proficiency with mammalian cell culture

    Extensive experience with protein biochemistry, including recombinant protein expression and purification and co-immunoprecipitations

    Experience with structural elucidation of viruses and/or oligomeric protein complexes including crystallography and/or CryoEM

    Effective oral and written communications skills.

    High personal ethical and quality standards.

    Exceptional problem solving and decision-making skills.

    Must be able to work productively in an interdisciplinary team environment

Additional Information:

    Occasional travel (mainly US).

Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status

Education Requirement:
PhD degree in virology, immunology, structural biology, molecular biology or related scientific discipline and/or M.D. or D.V.M.
Research and Early Development
2500 Innovation Way
Greenfield , Indiana 46140
Jared Patch, PhD