Postdoctoral position/lab technician in virology

University of Rochester

Categories:
  • Lab Technician
  • Post Doctoral Position - Academic
Job Type/Arrangement:
  • Full Time
Description:

The Sun lab is located in the Immunology and Microbiology department of the Medical School at University of Rochester. We are recruiting a post-doctoral researcher/scholar or a lab technician to start immediately. The lab focuses on understanding molecular mechanisms of the generation of defective viral genomes (DVGs). DVGs are a discrete subset of viral products generated during viral infection. They are truncations of the viral genome that lack the ability to complete replication unless complemented with a homologous helper virus. Evidences show that they play a critical role in viral pathogenesis. My lab will use Respiratory syncytial virus (RSV), a leading cause of respiratory illness in children worldwide, as the model to understand how DVGs are generated during infection and how manipulation of their generation impact infection outcome. 

So far, there are no vaccines or effective treatments available for RSV. RSV generates one specific type of DVGs, copy-back DVGs (cbDVGs). Despite growing evidence suggesting that cbDVGs impact RSV pathogenesis in mice and in humans, the mechanisms driving cbDVG generation remain unknown. This is largely due to the highly diverse species and kinetics of DVG generation during viral infection, and the lack of tools to examine them systematically. In order to overcome this problem, we developed an algorithm to survey entire cbDVG populations during infection. We have found that despite variation in cbDVG species among RSV infections, cbDVG generation is directed by certain genomic signals. The fact that de novo DVG generation is not stochastic strongly implies that virus and even host use unknown mechanisms to regulate DVG generation. We are studying the mechanism of cbDVG generation and identifying factors that influence their generation. The goal of  current research is to identify those unknown factors and expand the study to other viral families. 


Several questions will be focused on in the lab including:


1. What is the molecular mechanism regulating cbDVG generation in RSV?

2. Can we alter viral pathogenesis by manipulating de novo cbDVG generation during viral replication?

3. Are there common mechaniams controlling cbDVGs generation among different viral families, including paramyxoviruses (measles and parainfluenza), pneumoviruses (metapeumoviruses and RSV), and filoviruses (Ebola)?

4. What are the host factors impacting cbDVG generation?

5. How does the microenvironment influence cbDVG generation?

Interested candidates should submit a cover letter and CV to Dr. Yan Sun (yan_sun@urmc.rochester.edu).

Education Requirement:
For postdoctoral position: PhD in Virology, Microbiology, Immunology, or related field. For lab tech: An undergraduate degree (B.A. or B.S.) or equivalent in biology, chemistry, immunology, microbiology, molecular and cellular biology, or similar science-related field is required. 1-2 year of experience working in the virology lab is a plus.
Years of Experience:
Less than 3 years
Required Skills & Areas of Study:
  • molecular virology
Salary:
NIH guideline
Notes:

Please visit our lab website https://www.urmc.rochester.edu/people/31871877-yan-sun.

Location:
Rochester, NY
Microbiology and Immunology
601 Elmwood Ave
Rochester , NY 14642
US
Contact:
Yan Sun, PhD