Postdoctoral Researcher in Rotavirus-intestinal immunity

Washington University in St. Louis

  • Post Doctoral Position - Academic
Job Type/Arrangement:
  • Full Time

The Ding lab is newest member of the Department of Molecular Microbiology at Washington University School of Medicine (WUSTL). Our lab is interested in studying the replication of enteric viruses (in particular rotaviruses) and how they interact with the host innate immune system in the small intestine. Rotaviruses are highly virulent pathogens that cause diarrhea and an annual death of over 200,000 worldwide. We have employed a variety of high-throughput protein-protein interactome and CRISPR-Cas9 genetic screen approaches to understand rotavirus-host interactions (Ding S, PLOS Pathog, 2016; Li B and Ding S, PNAS, 2017; Ding S, Nat Comm, 2018; Ren L and Ding S, JBC, 2019). We are also intrigued by the different antiviral mechanisms in the host intestinal epithelium mounted against rotavirus and various strategies the virus uses to evade these restrictions (Zhu S and Ding S, Nature, 2017; Ding S, eLife, 2018). We are looking for highly motivated individuals to join our lab and work on the exciting interface of virology, immunology and intestinal biology!

For postdoctoral positions, successful candidates are expected to have a Ph.D., M.D, or equivalent degree in Microbiology/Immunology or related fields. In addition, candidates should be highly motivated, have strong communication skills, and be able to collaborate and work independently. Prior experience in working with viruses and animals is preferred. The Ding lab currently has opportunities for postdoctoral researchers to study the role of host factors in supporting rotavirus replication and virus innate immune evasion. These studies involve the use of newly developed rotavirus reverse genetics system and molecular biology approaches. There is also a postdoctoral position to study the molecular basis by which rotavirus induces diarrheal diseases and dictates host range/tissue tropism using a suckling mouse model for rotavirus pathogenesis and human intestinal organoids.

To apply, please email your cover letter summarizing your research interests, past research experience, and future career goals, curriculum vitae or NIH biosketch, and the names and contact information for 3 references to Dr. Siyuan Ding (

Education Requirement:
PhD, MD, or equivalent
Washington University School of Medicine in St. Louis
Department of Molecular Microbiology
4940 Parkview Place
Rm 9220
St. Louis , MO 63110
Siyuan Ding, PhD