Postdoctoral positions are available in the laboratory of Profs. James Chodosh and Jaya Rajaiya at Mass Eye and Ear, Harvard Medical School, Boston. Our laboratory studies the biology and evolution of human adenoviruses in three principle areas:
1) Innate immune responses to virus infection: We developed a mouse model of adenovirus keratitis, and used it to show that viral capsid was the major molecular pattern for innate immune responses in the cornea (1, 2). Currently, we are investigating the specific roles of unique cell types present on the eye surface in the early innate immune responses to viral infection. We want to elucidate the unique interactions between specific molecular patterns expressed by the adenovirus and individual cell phenotypes.
2) Adenoviral entry and trafficking: Viral entry is a complex phenomenon, and might be governed by the tropism of the pathogen, but is also cell type dependent. The pathway of entry also determines the type of proinflammatory responses elicited by the pathogen. In support to our recent work (3-5), there is a need to understand the specifics of entry in relation to the tropism of the virus.
3) Adenovirus genomics and evolution: Concurrent with our interest in molecular patterns and innate immunity, we have turned our attention more closely to the adenovirus pathogen as a physical entity, and have completed whole genome sequencing of all the remaining unsequenced human adenoviral prototypes. This led to our confirmation of homologous recombination as a major mechanism for evolution of the virus (6-8). Our current focus is to understand the molecular basis for homologous recombination between human adenoviruses.
The successful candidate is expected to be independent, collaborative, and promote a collegial workplace.
Please send a cover letter and CV to Profs. Chodosh and Rajaiya: James_Chodosh@meei.harvard.edu and Jaya_Rajaiya@meei.harvard.edu
1. Chintakuntlawar, A. V., X. Zhou, J. Rajaiya, and J. Chodosh. 2010. Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis. PLoS Pathog 6:e1000841.
2. Zhou, X., M. Ramke, A. V. Chintakuntlawar, J. Y. Lee, J. Rajaiya, and J. Chodosh. 2017. Role of MyD88 in adenovirus keratitis. Immunol Cell Biol 95:108-116.
3. Lee, J. S., A. M. Ismail, J. Y. Lee, X. Zhou, E. C. Materne, J. Chodosh, and J. Rajaiya. 2019. Impact of dynamin 2 on adenovirus nuclear entry. Virology 529:43-56.
4. Yousuf, M. A., X. Zhou, S. Mukherjee, A. V. Chintakuntlawar, J. Y. Lee, M. Ramke, J. Chodosh, and J. Rajaiya. 2013. Caveolin-1 associated adenovirus entry into human corneal cells. PLoS One 8:e77462.
5. Yousuf, M. A., J. S. Lee, X. Zhou, M. Ramke, J. Y. Lee, J. Chodosh, and J. Rajaiya. 2016. Protein Kinase C Signaling in Adenoviral Infection. Biochemistry 55:5938-5946.
6. Robinson, C. M., G. Singh, J. Y. Lee, S. Dehghan, J. Rajaiya, E. B. Liu, M. A. Yousuf, R. A. Betensky, M. S. Jones, D. W. Dyer, D. Seto, and J. Chodosh. 2013. Molecular evolution of human adenoviruses. Sci Rep 3:1812.
7. Ismail, A. M., T. Cui, K. Dommaraju, G. Singh, S. Dehghan, J. Seto, S. Shrivastava, N. B. Fedorova, N. Gupta, T. B. Stockwell, R. Halpin, R. Madupu, A. Heim, A. E. Kajon, E. G. Romanowski, R. P. Kowalski, J. Malathi, K. L. Therese, H. N. Madhavan, Q. Zhang, L. J. Ferreyra, M. S. Jones, J. Rajaiya, D. W. Dyer, J. Chodosh, and D. Seto. 2018. Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect 7:10.
8. Lee, J. Y., J. S. Lee, E. C. Materne, R. Rajala, A. M. Ismail, D. Seto, D. W. Dyer, J. Rajaiya, and J. Chodosh. 2018. Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection. mSphere 3.
9. Dehghan, S., J. Seto, E. B. Liu, A. M. Ismail, R. Madupu, A. Heim, M. S. Jones, D. W. Dyer, J. Chodosh, and D. Seto. 2019. A zoonotic adenoviral human pathogen emerged through genomic recombination amongst human and nonhuman simian hosts. J Virol. JVI.00564-19.