We are seeking postdoctoral associates at the Center for Integrated Solutions for Infectious Diseases (CISID, www.cisid.org) in the Broad Institute of MIT and Harvard. Successful applicants will be co-mentored by Drs. Seungmin “Sam” Hwang, Deb Hung and Ramnik Xavier.

In this position, the postdoctoral fellows are expected to investigate the mechanisms of organ dysfunction and immune paralysis in sepsis using clinical samples and animal models. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite considerable advances over the last decades, sepsis is still a leading cause of death in intensive care units, and survivors develop prolonged immune paralysis leading to a high incidence of recurrent infections. In the absence of definitive therapy, physicians rely on supportive care. Our team is devoted to deep understanding of immune dysfunction in sepsis for novel therapeutic hypotheses, through close collaboration with Harvard teaching hospitals.

Qualified candidates should have:

- PhD in immunology, microbiology, genetics, or a closely related field

- Records of leading projects successfully through publications in scientific journals and presentations in scientific conferences

- Solid understanding and hands-on experiences in immunological and microbiological assays, characterizing and modulating primary cells from humans and mice in the presence and absence of infection

- Experiences in functional genomics like CRISPR screens, next generation sequencing, and single-cell data is a big plus

- Excellences in written and oral communication, organization, and time management

- Motivation to take initiatives to learn new skills and drive projects to completion

- Willingness to engage with other members of the scientific community and contribute ideas through various meetings and discussions

We are committed to mentoring trainees for their career development and advancement through regular 1:1 meetings with the PI, active peer learning within the lab, and extensive collaboration with other labs at CISID and the Broad Institute.

To apply, please send your CV and cover letter with contact information for at least three references who are familiar with your academic performance and/or research experiences, through this job site .